The name PBLite allows for differentiating the procedure with ECHOLASER (micro-invasiveness and multi-fibre approach in a single system) from the other thermal ablation techniques.[\/vc_column_text][mk_fancy_title color=”#252f5a” size=”20″ font_weight=”600″ font_family=”Titillium+Web” font_type=”google”]Indications[\/mk_fancy_title][vc_column_text css=”.vc_custom_1515093818829{margin-bottom: 0px !important;}”]PBLite is indicated in the treatment of primitive and secondary liver cancer in the form of focal lesions. PBLite is also a safe and effective treatment of those who, due to critical medical conditions, are not able to undergo surgery.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][mk_padding_divider][\/vc_column][\/mk_page_section][mk_page_section bg_position=”right center” bg_repeat=”no-repeat” sidebar=”sidebar-1″][vc_column][vc_video link=”https:\/\/www.youtube.com\/watch?v=1iT31O5TEs0″ custom_thumbnail=”true” play_icon_size=”64″ thumbnail_image=”6045″][\/vc_column][\/mk_page_section][mk_page_section min_height=”0″ padding_top=”20″ padding_bottom=”20″ sidebar=”sidebar-1″][vc_column][mk_padding_divider size=”50″][vc_row_inner][vc_column_inner width=”1\/2″][mk_fancy_title color=”#252f5a” size=”20″ font_weight=”600″ font_family=”Titillium+Web” font_type=”google”]What is it?[\/mk_fancy_title][vc_column_text css=”.vc_custom_1515093845702{margin-bottom: 0px !important;}”]PBLite consists of the percutaneous insertion of optical fibres (from 1 to 4 depending on the size of the tumour), and the delivery of laser energy for several minutes which causes the heating of the tissues until they are completely destroyed with a sufficient safety margin. The positioning of the applicators, monitoring of the treatment and verification of the effective coagulation area are all carried out under ultrasound guidance. In order to facilitate the insertion manoeuvre, the system has dedicated multi-applicator Guiding Systems for ultrasound probes designed for the anatomical area of the liver with relative Biopsy Software that displays the guidelines on the screen. As these are malignant tumours, the objective of the treatment is complete ablation of the lesion and subsequent absence of post-treatment local relapses and a net increase in the long-term survival probabilities (5 years).[\/vc_column_text][mk_fancy_title color=”#0083c5″ size=”17″ line_height=”140″ font_weight=”500″ margin_bottom=”10″ font_family=”none”]With just one PBLite session it is possible to treat liver lesions with a very wide size range and diameters of up to 5 cm thanks to the versatility offered by the multi-fibre approach. The localized thermal effect of PBLite makes it the gold standard for liver lesions close to structures at risk.[\/mk_fancy_title][\/vc_column_inner][vc_column_inner width=”1\/2″][mk_padding_divider size=”50″][mk_gallery images=”6054,6055,6056,6057″ column=”2″ height=”600″ item_spacing=”0″][mk_fancy_title color=”#252f5a” size=”17″ font_weight=”600″ font_family=”Titillium+Web” font_type=”google”]Clockwise:
\n1.\/2. SI2C41 Esaote probe with dedicated multi-fibre Guiding System
\n3.\/4. CA541 Esaote probe with dedicated multi-fibre Guiding System[\/mk_fancy_title][\/vc_column_inner][\/vc_row_inner][mk_padding_divider][\/vc_column][\/mk_page_section][mk_page_section bg_image=”http:\/\/echolaser.pl\/wp-content\/uploads\/2017\/12\/s.png” bg_color=”#0582c8″ bg_position=”center center” bg_repeat=”no-repeat” enable_3d=”true” min_height=”0″ padding_top=”20″ padding_bottom=”20″ sidebar=”sidebar-1″][vc_column][mk_padding_divider size=”140″][mk_fancy_title color=”#ffffff” size=”20″ font_weight=”600″ font_family=”Titillium+Web” font_type=”google”]Advantages[\/mk_fancy_title][mk_fancy_title color=”#ffffff” size=”17″ line_height=”180″ font_weight=”500″ font_family=”none”]\n
Images by courtesy of Dr. Giovan Giuseppe Di Costanzo (Cardarelli Hospital, Naples)<\/em>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=”1\/2″][mk_fancy_title color=”#252f5a” size=”20″ font_weight=”600″ font_family=”Titillium+Web” font_type=”google”]Clinical Case no.2: [\/mk_fancy_title][mk_fancy_title color=”#0083c5″ size=”17″ line_height=”140″ font_weight=”500″ margin_bottom=”10″ font_family=”none”]Secondary colorectal cancer close to the heart[\/mk_fancy_title][vc_column_text css=”.vc_custom_1515094087458{margin-bottom: 0px !important;}”]A patient with an 8-mm metastasis of the liver in segment I extremely close to the pericardium, was subjected to Laser Thermotherapy. The lesion was completely ablated without any complications involving the critical neighbouring structures such as pericardial effusion.<\/p>\n[\/vc_column_text][mk_image src=”http:\/\/echolaser.pl\/wp-content\/uploads\/2017\/12\/imm3fegato.png” image_size=”full” margin_bottom=”30″][vc_column_text css=”.vc_custom_1515094099890{margin-bottom: 0px !important;}”]US image before the treatment[\/vc_column_text][mk_image src=”http:\/\/echolaser.pl\/wp-content\/uploads\/2017\/12\/imm4fegato.png” image_size=”full” margin_bottom=”30″][vc_column_text css=”.vc_custom_1515094120657{margin-bottom: 0px !important;}”]CEUS image after the treatment showing complete ablation<\/p>\n Images by courtesy of Dr. Sergio Sartori (Sant\u2019Anna Hospital, Ferrara)<\/em>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][mk_padding_divider size=”50″][\/vc_tab][vc_tab title=”Publications” tab_id=”1513096235305-3-5″][mk_padding_divider size=”80″][vc_column_text css=”.vc_custom_1515094189284{margin-bottom: 0px !important;}”]Efficacy and safety of percutaneous laser ablation therapy for treatment of large HCC.<\/u><\/strong> Laser ablation with or without chemoembolization for unresectable neuroendocrine liver metastases: a pilot study<\/u><\/strong> Laser ablation for small hepatocellular carcinoma: State of the art and future perspectives.<\/u><\/strong> Radiofrequency Ablation versus Laser Ablation for the Treatment of Small Hepatocellular A novel needle guide system to perform percutaneous laser ablation of liver tumors using the multifiber technique.<\/u><\/strong> Effectiveness, Safety, and Local Progression After Percutaneous Laser Ablation for Hepatocellular Carcinoma Nodules up to 4 cm Are Not Affected by Tumor Location<\/u>\u00a0<\/strong> Influence of ablative margin on local tumor progression and survival in patients with HCC \u22644 cm after laser ablation.<\/u><\/strong> Percutaneous laser ablation of hepatocellular carcinoma in patients with liver cirrhosis awaiting liver transplantation<\/u>\u00a0<\/strong> Long-term outcome of cirrhotic patients with early hepatocellular carcinoma treated with ultrasound-guided percutaneous laser ablation: a retrospective analysis<\/u><\/strong> Percutaneous laser ablation of unresectable primary and metastatic adrenocortical carcinoma<\/u><\/strong> Complications of Laser Ablation for Hepatocellular Carcinoma: A Multicenter Study<\/u><\/strong> Percutaneous laser ablation in patients with isolated unresectable liver metastases from colorectal cancer: Results of a phase II study.<\/strong> Analysis of factors predicting survival in patients with hepatocellular carcinoma treated with percutaneous laser ablation.<\/u><\/strong> Percutaneous Laser Ablation in the Treatment of Hepatocellular Carcinoma with a Tumor Size of 4 cm or Smaller: Analysis of Factors Affecting the Achievement of Tumor Necrosis<\/u><\/strong> Laser Thermal Ablation in the Treatment of Small Hepatocellular Carcinoma: Results in 74 Patients<\/u><\/strong> Hepatocellular Carcinoma: Long-term Results of Combined Treatment with Laser Thermal Ablation and Transcatheter Arterial Chemoembolization<\/u><\/strong> Ultrasound-guided percutaneous laser ablation of liver tissue in a rabbit model<\/u><\/strong> Randomised Clinical Trial [mk_page_section bg_color=”#ededed” bg_position=”right center” bg_repeat=”no-repeat” full_width=”true” js_vertical_centered=”true” sidebar=”sidebar-1″][vc_column][vc_row_inner el_id=”products_icons”][vc_column_inner][mk_image src=”http:\/\/echolaser.pl\/wp-content\/uploads\/2017\/12\/modi-lite.png” image_size=”full” link=”\/en\/thyroid-2\/” align=”right” margin_bottom=”-10″ animation=”fade-in”][mk_image src=”http:\/\/echolaser.pl\/wp-content\/uploads\/2017\/12\/soracte-lite.png” image_size=”full” link=”\/en\/prostate\/” align=”right” margin_bottom=”-10″ animation=”fade-in”][mk_image src=”http:\/\/echolaser.pl\/wp-content\/uploads\/2017\/12\/pb-lite-e1515084571108.png” image_size=”full” link=”\/en\/liver\/” align=”right” margin_bottom=”-10″ animation=”fade-in”][mk_image src=”http:\/\/echolaser.pl\/wp-content\/uploads\/2017\/12\/agatha-lite.png” image_size=”full” link=”\/en\/breast\/” align=”right” margin_bottom=”-10″ animation=”fade-in”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/mk_page_section][mk_page_section bg_image=”http:\/\/echolaser.pl\/wp-content\/uploads\/2018\/01\/echolaser_watroba.jpg” bg_position=”center center” bg_repeat=”no-repeat” bg_stretch=”true” sidebar=”sidebar-1″][vc_column][mk_padding_divider size=”500″][\/vc_column][\/mk_page_section][mk_page_section bg_color=”#ededed” bg_position=”right center” bg_repeat=”no-repeat” sidebar=”sidebar-1″][vc_column][mk_fancy_title color=”#0c3383″ size=”30″ line_height=”130″ font_weight=”500″ margin_top=”20″ font_family=”none” align=”center”]Why abandon the idea […]<\/p>\n","protected":false},"author":13,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"","meta":[],"yoast_head":"\n
\nCamera S, Di Costanzo GG, Tortora R, Addario L, Lampasi F, Tartaglione MT, Cossiga V, Donnaruma L, Caporaso N, Morisco F.\u00a0<\/em>
\nDigestive and Liver Disease. 2016; 48 (1): e50.<\/p>\n
\nPacella CM, Nasoni S, Grimaldi F, Di Stasio E,Misischi I, Bianchetti S, Papini E.\u00a0<\/em>
\nInternational Journal of Endocrine Oncology May 2016, Vol.3, No.2, Pages 97-107<\/p>\n
\nDi Costanzo GG, Francica G, Pacella CM.<\/em>
\nWorld J Hepatol 2014 October 27; 6(10): 704-715<\/p>\n
\nCarcinoma in Cirrhosis: a Randomized Trial.<\/u><\/strong>
\nDi Costanzo GG, Tortora R, D Adamo G, De Luca M, Lampasi F, Addario L, Galeota Lanza A, Picciotto FP, Tartaglione MT, Cordone G, Imparato M, Mattera S, Pacella CM.<\/em>
\nJ Gastroenterol Hepatol. 2015 Mar;30(3): 559-65<\/p>\n
\nDi Costanzo GG, D\u2019Adamo G, Tortora R, Zanfardino F, Mattera S, Francica G, Pacella CM.<\/em>
\nActa Radiol. 2013 May 23.<\/p>\n
\nFrancica G, Petrolati A, Di Stasio E, Pacella S, Stasi R, Pacella CM.<\/em>
\nVascular and Interventional Radiology 2012 February;199:1393\u20131401<\/p>\n
\nFrancica G, Petrolati A, Di Stasio E, Pacella S, Stasi R, Pacella CM.<\/em>
\nActa Radiol. 2012 May 1;53(4):394-400.<\/p>\n
\nPompili M, Pacella CM, Francica G, Angelico M, Tisone G, Craboledda P, Nicolardi E, Rapaccini GL, Gasbarrini G.<\/em>
\nEur J Radiol. 2009
\nReview Article: Laser Ablation for Small Hepatocellular Carcinoma<\/u><\/strong>
\nPacella CM, Francica G, and Di Costanzo GG<\/em>.
\nRadiology Research and Practise. 2011 Oct 20<\/p>\n
\nPacella CM, Francica G, Di Lascio FM, Arienti V, Antico E, Caspani B, Magnolfi F, Megna AS, Pretolani S, Regine R, Sponza M, Stasi R.<\/em>
\nJ Clin Oncol. 2009 Jun 1;27(16):2615-21<\/p>\n
\nPacella CM, Stasi R, Bizzarri G, Pacella S, Graziano FM, Guglielmi R, Papini E.<\/em>
\nEur J Radiol. 2008 Apr; 66 (1):88-94<\/p>\n
\nArienti V, Pretolani S, Pacella CM, Magnolfi F, Caspani B, Francica G, Megna AS, Regine R, Sponza M, Antico E, Di Lascio FM<\/em>.
\nRadiology. 2008 Mar;246(3):947-55. Epub 2008 Jan 14.<\/p>\n
\nPacella CM, Valle D, Bizzarri G, Pacella S, Brunetti M, Maritati R, Osborn J, Stasi R.\u00a0<\/em>
\nActa Oncologica 2006; 45: 77-83<\/p>\n
\nPacella CM, Bizzarri G, Francica G, Forlini G, Petrolati A, Valle D, Anelli V, Bianchini A, Nuntis SD, Pacella S, Rossi Z, Osborn J, Stasi R.\u00a0<\/em>
\nJ Hepatol. 2006 Maggio;44(5):902-9<\/p>\n
\nWalser EM<\/em>
\nJ Vasc Interv Radiol 2005; 16:1427\u20131429<\/p>\n
\nPacella CM, Bizzarri G, Magnolfi F, Cecconi P, Caspani B, Anelli V, Bianchini A, Valle D, Pacella S, Manenti G, Rossi Z.\u00a0<\/em>
\nRadiology. 2001 Dec; 221(3):712-20.<\/p>\n
\nPacella CM, Bizzarri G, Cecconi P, Caspani B, Magnolfi F, Bianchini A, Anelli V, Pacella S, Rossi Z<\/em>.
\nRadiology. 2001 Jun;219(3):669-78<\/p>\n
\nPacella CM, Rossi Z, Bizzarri G, Papini E, Marinozzi V, Paliotta D, Castaldo R, Ziparo V, Garosi F, Cinti M, Muzzi F<\/em>
\nEuropean Radiology 1993; 3(1)[\/vc_column_text][\/vc_tab][vc_tab title=”Clinical Trials” tab_id=”1513101238259-2-3″][mk_padding_divider size=”80″][mk_fancy_title color=”#0083c5″ size=”17″ line_height=”140″ font_weight=”500″ margin_bottom=”10″ font_family=”none”]Radiofrequency Versus Laser Ablation for Hepatocellular Carcinoma[\/mk_fancy_title][vc_column_text css=”.vc_custom_1515094234087{margin-bottom: 0px !important;}”]\n
\nNo. of patients enrolled: 140
\nReference Study Centre: Cardarelli Hospital, Naples
\nStudy Status: Completed
\nRegistered on ClinicalTrial.gov:\u00a0https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01096914?term=laser+radiofrequency+liver&rank=1<\/a>
\nPublication of the results:\u00a0Radiofrequency ablation versus laser ablation for the treatment of small hepatocellular carcinoma in cirrhosis: A randomized trial<\/a>, Di Costanzo GG1, Tortora R, D\u2019Adamo G, De Luca M, Lampasi F, Addario L, Galeota Lanza A, Picciotto FP, Tartaglione MT, Cordone G, Imparato M, Mattera S, Pacella CM. J Gastroenterol Hepatol. 2015 Mar;30(3):559-65.<\/p>\n[\/vc_column_text][\/vc_tab][\/vc_tabs][\/vc_column][\/mk_page_section][vc_row][vc_column][vc_row_inner][vc_column_inner][mk_padding_divider size=”100″][vc_separator][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"